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Growth-factor ligand functionalization enhances cellular and in vivo uptake of DNA nanodevices

Biswas, A.; Naveena, H. A.; Kansara, K.; Parma, B.; Shekhar, V.; Kumar, D. A.; Gupta, S.; Bhatia, D.

2025-08-02 bioengineering
10.1101/2025.08.01.668157 bioRxiv
Show abstract

Epidermal Growth Factor (EGF) and Transforming Growth Factor beta (TGF-{beta}) are two important classes of growth factor that regulates cell growth, cell proliferation, differentiation, immune responses, and extracellular matrix generation. Using a short peptide-based ligand coupled to DNA nanocages, we present the enhanced internalization of a receptor-mediated peptide-DNA nanocage. We used here tdDNA as a delivery vehicle. Our study in cellular and in vivo showed excellent internalization, cell growth, and inhibition. We expect that a tdDNA-modified receptor-binding peptides could become a valuable scaffold for use as a cellular programming and regenerative material.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.