Advancing Non-Invasive Respiratory Diagnostics: Multiplex Nasal Biomarker Profiling for Stratification of Airway Inflammatory Diseases

2025-08-05 respiratory medicine Title + abstract only

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This study explores the potential of nasal secretions to serve as a source of biomarkers for diagnosing respiratory conditions. A total of 40 inflammatory biomarkers were detected and quantified in participants with upper respiratory diseases, including chronic rhinosinusitis (CRS), allergic rhinitis, and viral and bacterial infections. The different expression levels of various biomarkers could distinguish CRS participants with and without nasal polyps (i.e. CRP, GzmB, IL-4, MMP-1, MMP-8, SAA a...