OXA-1207, a new OXA-48-type carbapenem-hydrolysing class D beta lactamase from Escherichia coli
Sommer, J.; Welter, M.; Krause, F. F.; Goettig, S.
Show abstract
1.We present the characterisation of OXA-1207, a novel, plasmid-encoded OXA-48-like carbapenemase identified in two unrelated Escherichia coli (sequence type (ST) ST405 and ST4405) isolates from hospital patients in Germany. OXA-1207 is closely related to OXA-181, differing by two amino acid substitutions (214G and 244W). The blaOXA-1207 gene was located on a self-transmissible IncFIC plasmids (pOXA-1207) featuring a conserved backbone and the novel {Delta}Tn6361 transposon structure, which derived from IncX3 plasmids carrying blaOXA-181. Notably, pOXA-1207 exhibited an exceptionally high conjugation frequency (mean 1.2 x 10-1) to E. coli, surpassing the typical rates reported for widely distributed OXA-48 plasmids. Analysis of public genomic datasets identified 40 E. coli isolates carrying blaOXA-1207, belonging to diverse high-risk clonal lineages (ST167, ST405 and ST410). The isolates originated from multiple continents, indicating global dissemination. These findings highlight OXA-1207 as an emerging and concerning resistance determinant with enhanced transmissibility and emphasise the need for continued molecular surveillance of OXA-48-like carbapenemases.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Inter-phylum circulation of a beta-lactamase - encoding gene: a rare but observable event 97%
- Novel quinolone resistance determinant, qepA8, in Shigella flexneri isolated in the United States, 2016 97%
- Molecular epidemiology of third-generation cephalosporin-resistant Enterobacteriaceae from Southeast Queensland, Australia 96%
Similar papers in this journal
- blaOXA-48-like genome architecture among carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in the Netherlands 99%
- Diversity of carbapenem-resistant Acinetobacter baumannii and bacteriophage-mediated spread of the Oxa23 carbapenemase 97%
- Genome-wide analysis in Escherichia coli unravels an unprecedented level of genetic homoplasy associated with cefotaxime resistance. 97%
Similar papers in this journal
- Identification of plasmid-mediated tigecycline resistance tet(x4) and New Delhi Metallo-β-lactamase (NDM) in an Escherichia coli isolate from Canada 97%
- Global dissemination of tet(X3) and tet(X6) among livestock-associated Acinetobacter is sporadically mediated by highly diverse plasmidomes 97%
- Evolution of chlorhexidine susceptibility and of the EfrEF operon among Enterococcus faecalis from diverse environments, clones and time spans 96%
Similar papers in this journal
- Emergence of a cephalosporin reduced susceptible Neisseria gonorrhoeae clone between 2014-2019 in Amsterdam, the Netherlands, revealed by a genomic population analysis 96%
- Variability in carbapenemase activity of intrinsic OxaAb (OXA-51-like) beta-lactamase enzymes in Acinetobacter baumannii 96%
- Consideration of within-patient diversity highlights transmission pathways and antimicrobial resistance gene variability in vancomycin resistant Enterococcus faecium 95%
Similar papers in this journal
- Transmissible antimicrobial resistance in Escherichia coli isolated from household drinking water in Ibadan, Nigeria 97%
- Whole genome sequences of multi-drug resistant Escherichia coli isolated in a Pastoralist Community of Western Uganda: Phylogenomic changes, virulence and resistant genes 97%
- Molecular investigations on a chimeric strain of Staphylococcus aureus sequence type 80 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.