Oncogenomic profiling of cutaneous pericytic tumours reveals distinct drivers and shared biological processes
Del Castillo Velasco-Herrera, M.; Cheema, S.; Wong, K.; Billington, J.; Vermes, I.; Anderson, E.; Ferla, E.; Harms, P. W.; de Saint Aubain, N.; Clarke, E. L.; Merchant, W.; Alomari, A. K.; Rajan, N.; Ferguson, P.; Weigelt, M. A.; Monteagudo, C.; Billings, S. D.; Arends, M. J.; Ferreira, I.; Brenn, T.; van der Weyden, L.; Adams, D. J.
Show abstract
To-date the genomic landscape of cutaneous pericytic tumours (PTs), which represent a morphological continuum, have not been comprehensively explored. In order to identify the driver events of PTs from across their histological spectrum, and potentially aid the current classification system, we sequenced DNA (whole-exome) and RNA (pulldown transcriptome) from tumour-normal pairs classified by two different dermatopathologists of angioleiomyoma (n=37), glomus tumour (n=30) and myopericytoma (n=11); with all sequencing data deposited in the European Genome and Phenome Archive.
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