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Allostatic (over)Load Measurement: Workflow and repository

Beese, S.; Cross, J.; Rice, D.; DeJong, T. L.

2025-08-01 health informatics
10.1101/2025.07.31.25332519 medRxiv
Show abstract

Researchers have long studied allostatic (over)load as an estimated measure of individual cumulative stress over a lifetime. Often called the overall wear and tear from social and environmental stressors, allostatic (over)load shows promise as a practical indicator of general health trends in community settings. This data processing workflow aims to document our overall approach and reasoning when calculating allostatic (over)load for data analysis and knowledge sharing. The included repository features an R script for generating datasets using this workflow from the following data sources: O_LIAll of Us Research Program data repository C_LIO_LIHealth and Retirement Study (HRS) C_LIO_LINational Health and Nutrition Examination Survey (NHANES) C_LI Our allostatic (over)load measurement process, along with the linked repository, provides a reproducible workflow to process secondary data and offers insights into protocol-driven measurement practices in community environments.

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