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The neurodevelopmental spectrum: phenotypic architecture, etiology, and predictive utility across development

2025-07-31 psychiatry and clinical psychology Title + abstract only
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Neurodevelopmental conditions are highly heritable, heterogeneous, and frequently co-occur with one another. Transdiagnostic dimensional approaches have advanced our understanding of psychiatric disorders and informed their classification, but have largely omitted neurodevelopmental conditions. We investigated the structure of a transdiagnostic "neurodevelopmental spectrum", its etiology, and its ability to predict functional outcomes across development, using longitudinal data for >10,000 twins...

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