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Large-scale plasma proteomics uncovers preclinical molecular signatures of Parkinson disease and overlap with other neurodegenerative disorders
2025-07-30
neurology
Title + abstract only
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BackgroundParkinsons disease (PD) remains incurable, with a long prediagnostic phase currently undetectable by existing methods. Identifying individuals at high risk of PD would enhance our understanding of the underlying pathophysiology and will open up new preventive or early therapeutic avenues. MethodsIn the largest proteomic study in neurodegenerative diseases to date, we analyzed blood samples from [~]74,000 individuals across discovery and validation cohorts. In the discovery phase, we l...
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