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CDS-PD: A Novel Clinical Decision Support Platform for Parkinson's Disease

Gupta, D. K.; Golnari, P.; Prantzalos, K.; Zurlo, I.; Iyer, V.; Lobb, B.; Zweber, C.; Bulusu, M.; Clarke, D.; Boyd, J. T.; Tatsuoka, C.; Hiller, A.; Sahoo, S. S.

2025-07-25 neurology
10.1101/2025.07.24.25331875
Show abstract

The Movement Disorders Society clinical diagnostic criteria for Parkinsons disease (MDS-PD) allow highly sensitive and specific diagnosis of Parkinsons disease. However, their adoption has been limited due to lack of a clinical decision support (CDS) tool to support clinicians and researchers in systematically and accurately applying the MDS-PD criteria. We have developed and performed preliminary validation of a CDS platform for PD (CDS-PD) as a modular and extensible informatics platform with comprehensive functionalities for recording relevant patient information. We have performed real-time application of diagnostic algorithm of the MDS-PD criteria. The CDS-PD platform shows high concordance with application of the MDS-PD criteria by experienced movement disorders neurologists for established PD (disease duration [≥]5 years). The CDS-PD platform is a step towards realizing the standardized electronic implementation of the MDS-PD criteria for PD patient care and clinical trials at point-of-care. The CDS-PD platform can be accessed after registration at weblink https://www.cdspd.org.

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