Back

Sex-stratified analysis of the potential association between PGLYRP2 rs892145 variant and Parkinson's disease across diverse ancestral populations

2025-07-24 genetic and genomic medicine Title + abstract only
View on medRxiv
Show abstract

Variants in PGLYRP2, particularly rs892145-T, have been suggested as Parkinsons disease (PD) risk factors. We analyzed data from 31,334 PD patients and 17,772 controls across diverse ancestries. A significant sex-dependent effect of rs892145-T was observed in African (AFR) ancestry males (OR=0.73, 95%CI: 0.57-0.94, p=0.014). Gene-based analyses identified another variant, rs7251871-A, as significantly associated with PD in AFR males (OR=1.34, 95%CI:1.13-1.59, p=6.65E-04, Bonferroni p=0.0432). No...

Predicted journal destinations

1
Movement Disorders
49 training papers
Top 0.2% 24.2%
2
Neurobiology of Aging
29 training papers
#1 12.9%
3
npj Parkinson's Disease
35 training papers
Top 0.9% 7.0%
4
Scientific Reports
701 training papers
Top 37% 6.5%
5
Brain
69 training papers
Top 3% 5.5%
6
Genetics in Medicine
57 training papers
Top 4% 3.0%
7
PLOS ONE
1737 training papers
Top 91% 2.1%
8
Translational Psychiatry
94 training papers
Top 6% 2.1%
9
Nature Genetics
72 training papers
Top 7% 1.7%
10
Nature Communications
483 training papers
Top 41% 1.7%
11
Frontiers in Genetics
32 training papers
Top 4% 1.5%
12
The American Journal of Human Genetics
77 training papers
Top 7% 1.5%
13
International Journal of Molecular Sciences
39 training papers
Top 2% 1.5%
14
Human Genetics and Genomics Advances
39 training papers
Top 6% 1.3%
15
Human Molecular Genetics
28 training papers
Top 5% 1.3%
16
Alzheimer's & Dementia
84 training papers
Top 8% 1.0%
17
European Journal of Human Genetics
25 training papers
Top 5% 1.0%
18
Annals of Neurology
43 training papers
Top 7% 1.0%
19
PLOS Genetics
39 training papers
Top 7% 1.0%
20
npj Genomic Medicine
18 training papers
Top 3% 1.0%
21
Annals of Clinical and Translational Neurology
22 training papers
Top 5% 0.8%
22
Brain Communications
79 training papers
Top 9% 0.8%
23
Molecular Psychiatry
84 training papers
Top 9% 0.8%
24
Journal of Medical Genetics
22 training papers
Top 4% 0.8%
25
eLife
262 training papers
Top 51% 0.8%
26
Genome Medicine
56 training papers
Top 8% 0.8%
27
Cell Genomics
34 training papers
Top 7% 0.8%
28
Genes
21 training papers
Top 4% 0.8%
29
Biological Psychiatry
36 training papers
Top 7% 0.5%
30
Neuropsychopharmacology
29 training papers
Top 6% 0.5%