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Cathepsins and Glaucoma: Genetic Evidence from a Mendelian Randomization Approach
2025-07-21
ophthalmology
Title + abstract only
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BackgroundGlaucoma is a progressive optic neuropathy primarily associated with elevated intraocular pressure (IOP) and characterized by optic nerve damage. Despite numerous risk factors, including high IOP, the molecular mechanisms underlying glaucoma remain unclear. The cathepsin family, a group of lysosomal proteases, plays a critical role in various physiological and pathological processes. This study investigates the causal relationship between cathepsins and glaucoma using Mendelian Randomi...
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