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Methylome-Wide Association Study of Obsessive-Compulsive Disorder

2025-07-21 psychiatry and clinical psychology Title + abstract only
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BackgroundObsessive-compulsive disorder (OCD) is a debilitating psychiatric condition influenced by both genetic and environmental risk factors. Epigenetic modifications, such as DNA methylation, may offer insights into biologically meaningful differences associated with the disorder. MethodsWe conducted the largest methylome-wide association study (MWAS) of OCD to date, analyzing saliva DNA samples from 414 individuals with OCD and 384 controls using the Illumina EPICv2 array. Differentially m...

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