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A measurement model to quantify systemic bacilli load in severe HIV-associated tuberculosis

Sossen, B.; Schutz, C.; Boloko, L.; Broger, T.; Ward, A.; Bekiswa, A.; Balfour, A.; Shey, M.; Meintjes, G.; Barr, D. A.

2025-07-18 infectious diseases
10.1101/2025.07.18.25331763 medRxiv
Show abstract

Systemic mycobacterial load is associated with outcome in HIV-associated tuberculosis but is poorly defined. We used latent variable modelling to characterise HIV-associated TB mycobacterial load. Mycobacterium tuberculosis detection tests on urine and blood, but not sputum, showed substantial co-variance, and were strongly correlated with host inflammation and mortality.

Published in Open Forum Infectious Diseases (predicted rank #21) · training set

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