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Association of ADAM33 Gene rs2280091 (T1) Polymorphism with Asthma Severity in Syrian Population: A Case-Control Study Using PCR-RFLP Analysis
2025-07-18
respiratory medicine
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BackgroundAsthma is a complex chronic inflammatory disease affecting approximately 339 million people worldwide. The ADAM33 gene, encoding a disintegrin and metalloproteinase, has emerged as a key susceptibility gene for asthma, with the rs2280091 (T1) polymorphism showing variable associations across different populations. This study represents the first genetic investigation of asthma in the Syrian population. MethodsA case-control study was conducted at Aleppo University Hospital from April ...
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