Causes of Neonatal Mortality in the European Region: A WHO-based analysis and Systematic Review

AO_SCPLOWBSTRACTC_SCPLOWO_ST_ABSPurposeC_ST_ABSDespite considerable progress in reducing neonatal mortality, significant work remains. The regional differences in both the rates and causes of neonatal mortality, necessitates addressing this issue within a regional context. This study aimed to identify reported causes of neonatal death in the European Region and examine the cause-specific distribution of neonatal deaths over time. MethodsWe conducted a two-pronged analysis: (1) database analysis using WHO public datasets (2000-2021) for 28 countries in the European Region and (2) a systematic review and meta-analysis of pertinent records from various databases which were comprehensively reviewed against inclusion criteria up to 10th August 2024, following PRISMA guidelines. ResultsThe average neonatal mortality rate between 2000-2021 in WHO data was 2.63 per 1,000 live births, with a significant decline (-0.074 per year) across the European Region. Prematurity (41.2%) and congenital anomalies (28.9%) were the most common registered causes of neonatal death; no detailed etiological breakdown was available. The systematic review identified 41 eligible studies; 14 could be included in meta- analyses. Pooled estimates showed that congenital anomalies and prematurity each accounted for 30% of deaths. Among extremely preterm neonates, infections, respiratory and cardiovascular disorders were the most common reported causes of death. ConclusionsNMRs across the European Region is declining (rapidly) with prematurity and congenital anomalies being leading causes of neonatal death. Current mortality reporting frameworks inadequately capture the diagnostic complexity of neonatal death causes. Adoption of detailed, standardized classification systems is critical to improving surveillance and data comparability, especially for preterm infants. WO_SCPLOWHATC_SCPLOWO_SCPCAP C_SCPCAPO_SCPLOWISC_SCPLOW KO_SCPLOWNOWNC_SCPLOWO_LINeonatal mortality rates have declined across Europe over recent decades. C_LIO_LIThere are considerable regional disparities in both causes and rates of neonatal death. C_LI WO_SCPLOWHATC_SCPLOWO_SCPCAP C_SCPCAPO_SCPLOWISC_SCPLOW NO_SCPLOWEWC_SCPLOWO_LIPrematurity and congenital anomalies each account for [~]30% of neonatal deaths. C_LIO_LIIn extremely preterm infants, infections and cardiorespiratory disorders predominate. C_LIO_LIGreater use of standardised classifications of neonatal death causes is urgently needed. C_LI