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Pathway-based genetic susceptibility and cleaning agent exposures in adult asthma: A semi explorative G x E analysis in the Personalized Environment and Gene Study (PEGS)
2025-06-30
respiratory medicine
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BackgroundPathway-based approaches may effectively dissect the polygenic architecture of complex diseases. We conducted a semi-explorative interaction study between genome-wide and pathway-specific polygenic risk scores (PRS) and occupational asthmagens (i.e., cleaning agents) on adult asthma. MethodsThis study included 2615 adults from the Personalized Environment and Genes Study (PEGS) in North Carolina, with comprehensive questionnaire-based health and exposure data and whole genome sequenci...
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