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Asymmetrical Frontal-Subcortical Aberrance in ADHD: Empirical Support of a Developmental Network Model
2025-06-26
psychiatry and clinical psychology
Title + abstract only
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BackgroundThis study empirically tests a theoretical model of ADHD that identifies aberrant frontal-to-subcortical projections--particularly those involving the ventral tegmental area and, consequently, the nucleus accumbens (NAc)--as a core neurobiological vulnerability. The model predicts reduced frontal influence on subcortical structures and group-by-direction interaction effects, especially at the NAc. MethodsStructural and resting-state fMRI data from sixty individuals with ADHD and sixty...
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