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Family dynamics and environmental factors influencing progression from alcohol experimentation to initiation in youth: Evidence from the Adolescent Brain Cognitive Development (ABCD) Study

Harwood, M. I.; Otero-Leon, D. F.; Stringfellow, E. J.; Deutsch, A.; Jalali, M. S.; Dong, H.

2025-06-24 addiction medicine
10.1101/2025.06.23.25330149 medRxiv
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PurposeWhile a growing body of research categorizes early drinking behaviors into experimentation and initiation, factors driving the transition remain underexplored. This study examined individual and environmental influences on the time from alcohol experimentation to initiation among preadolescent youth. MethodsData came from the Adolescent Brain Cognitive Development (ABCD) Study (2016-2021). Experimentation was defined as first sip and initiation as first full drink during follow-up. Extended Cox models assessed the impact of sociodemographic factors, alcohol expectancies, family and peer dynamics, and neighborhood-level factors on the likelihood of alcohol initiation following experimentation. ResultsOf 1,213 youths, 87 (7.2%) progressed from sipping to drinking within 45 months. Older age at onset of sipping was associated with the highest likelihood of alcohol initiation (adjusted hazard ratio [HR]=6.40, 95% confidence interval [CI]: 3.72-11.02, p<0.001), followed by peer alcohol use (adjusted HR=4.11, 95% CI: 2.55-6.65, p<0.001), household rules allowing alcohol consumption (adjusted HR=2.14, 95% CI: 1.17-3.91, p=0.014), family conflict (adjusted HR=1.14, 95% CI: 1.04-1.26, p=0.007), and positive alcohol expectancies (adjusted HR=1.10, 95% CI: 1.01-1.21, p=0.032). Conversely, older chronological age was protective (adjusted HR=0.30, 95% CI: 0.18-0.51, p<0.001). No significant differences in the likelihood of alcohol initiation were observed based on sex, race, ethnicity, household income, parental drinking problems, alcohol availability, and neighborhood safety. DiscussionAge, social and familial influences, and positive alcohol expectancies play central roles in early drinking progression. Interventions that integrate individual beliefs, family practices, and peer dynamics should be considered for delaying initiation.

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