Anisotropy boosting improves ODF-Fingerprinting tractography in edematous brain
Filipiak, P.; Clarke, K.; Shepherd, T. M.; Bruno, M.; Placantonakis, D. G.; Baete, S. H.
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Peritumoral vasogenic edema of the brain is a major confounding factor for diffusion MRI tractography. Excessive fluids accumulated in edematous white matter decrease anisotropy of water self-diffusion which affects tracking algorithms. We address this hurdle with ODF-Fingerprinting (ODF-FP) -- a dictionary-based fiber reconstruction algorithm that accommodates variability of neural tissue. By adding a regularization term to the ODF-FP matching formula, we boost diffusion anisotropy to improve white matter fiber identification in edematous regions.
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