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Evaluating the role of liquid biopsy to detect pathogenic DNA Damage Repair (DDR) gene alterations in metastatic prostate cancer
2025-06-10
oncology
Title + abstract only
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BackgroundMetastatic prostate cancers frequently harbor pathogenic aberrations in DNA damage repair (DDR) genes, that confer sensitivity to PARP inhibitors (PARPi). Therefore, accurate identification of all eligible patients is needed. The development of circulating tumor DNA (ctDNA) testing alternative is promising as genomic testing of archived tissue leads to up to 30-40% failure rate in prostate cancer. MethodsThis was a bi-institutional retrospective cohort study of patients with metastati...
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