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Ketamine improves anhedonic phenotypes across species: Translational evidence from the Probabilistic Reward Task

2025-06-03 psychiatry and clinical psychology Title + abstract only
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BackgroundKetamine is increasingly used as a therapeutic option for treatment-resistant depression (TRD) due to its rapid antidepressant properties, yet the mechanisms underlying these effects remain elusive. Preclinical evidence suggests ketamine acts on neural pathways implicated in reward processing, but translational efforts have proven challenging, due to a lack of paradigms allowing for analogous assessment of depressive phenotypes across species. Here, we investigated the effects of a sin...

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