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Genetic signatures of bipolar disorder course specifiers
2025-05-18
genetic and genomic medicine
Title + abstract only
View on medRxiv
Show abstract
BackgroundBipolar disorder (BD) factor models offer limited dimensional understanding due to incomplete integration of psychosocial deficits, long-term outcomes, and transdiagnostic genetics, thus restricting personalised interventions. This study aimed to provide a holistic understanding of BD psychopathology, overcoming this limitation. MethodsExploratory Factor Analysis of 77 OPCRIT items revealed four psychopathological dimensions, and Confirmatory Factor Analysis validated a 20-item, four-...
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