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Development and validation of genomic biotypes for schizophrenia susceptibility from multiple polygenic scores
2025-04-30
psychiatry and clinical psychology
Title + abstract only
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1. ImportanceSchizophrenia is clinically and biologically heterogeneous, with marked variability in course and treatment response. Stratification of patients may advance individualized therapy and clarify underlying mechanisms. 2. ObjectiveTo identify, validate, and replicate genetic risk factors distinct to each other in schizophrenia patients using polygenic risk scores of large numbers of psychiatry-relevant phenotypes. 3. DesignWe analyzed genetic and phenotypic data from FinnGen (discover...
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