Neutralizing Antibody Responses After mRNA COVID-19 Booster Vaccination are Unaffected by Parasitemia in a Malaria-Endemic Setting
Samandari, T.; Achola, M.; Hutter, J. N.; Mboya, G.; Otieno, W.; Kee, J. J.; Huang, Y.; Aponte, J. J.; Ockenhouse, C. F.; Lee, C. K.; Polakowski, L. L. K.; Yacovone, M.; Tapley, A.; Dadabhai, S.; Mkhize, N. N.; Kaldine, H.; Bhebhe, S.; Moore, P.; Hural, J.; Garrett, N.; Kublin, J.
Show abstract
Subclinical malaria may reduce the immunogenicity of mRNA vaccines. We evaluated neutralizing antibody responses in adults with (n=87) and without (n=221) PCR-confirmed Plasmodium falciparum who received a COVID-19 booster. Similar boosted ID50 geometric mean titers >22,000 in parasitemic and non-parasitemic participants suggests that COVID-19 mRNA vaccine responses are not impaired.
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