1st, 2nd, and 3rd+ SARS-CoV-2 infections: associations of prior infections with protection and severity
Maier, H. E.; Ojeda, S.; Shotwell, A.; Lopez, R.; Sanchez, N.; Saborio, S.; Plazaola, M.; Barilla, C.; Kuan, G.; Balmaseda, A.; Gordon, A.
Show abstract
Since the emergence of the antigenically distinct Omicron variant, SARS-CoV-2 reinfections have increased and are common. Yet, as we approach endemicity, the frequency, severity, and consequences of reinfections remain poorly understood. Using data from a household transmission study in Managua, Nicaragua (2020-2024), we evaluated protection conferred by one, two, and three+ prior infections and compared the severity of first, second, and third+ RT-PCR-confirmed SARS-CoV-2 infections. In adults, compared to those with no prior infections, after adjusting for vaccination, one, two, and three+ prior infections were associated with increasing protection from symptomatic infection: 46%, (95% Confidence Interval [CI]: 32-57%), 69% (95%CI: 56-78%), and 77% (95%CI: 58-88%), respectively. Compared to first infections, second and third+ infections were associated with decreasing severity in adults, adjusted for vaccination; 35% (95%CI: 11-52%) and 42% (95%CI: 6-65%) less moderate/severe disease, and 152% (95%CI: 46-336%) and 243% (95%CI: 82-545%) more subclinical disease, respectively.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Viral dynamics of Omicron and Delta SARS-CoV-2 variants with implications for timing of release from isolation: a longitudinal cohort study 94%
- BNT162b2 mRNA Vaccine Effectiveness Given Confirmed Exposure; Analysis of Household Members of COVID-19 Patients 92%
- SARS-CoV-2 infection and post-acute risk of non-Covid-19 infectious disease hospitalizations: a nationwide cohort study of Danish adults aged ≥50 years 92%
Similar papers in this journal
- Typically asymptomatic but with robust antibody formation: Children’s unique humoral immune response to SARS-CoV-2 94%
- Increased vaccine sensitivity of an emerging SARS-CoV-2 variant 93%
- Waning of SARS-CoV-2 antibodies targeting the Spike protein in individuals post second dose of ChAdOx1 and BNT162b2 COVID-19 vaccines and risk of breakthrough infections: analysis of the Virus Watch community cohort 93%
Similar papers in this journal
- Anti-membrane and anti-spike antibodies are long-lasting and together discriminate between past COVID-19 infection and vaccination 93%
- The effect of pre-existing coronavirus antibodies on SARS-CoV-2 infection outcomes in exposed household members 93%
- Correlation between post-vaccination titres of combined IgG, IgA, and IgM anti-Spike antibodies and protection against breakthrough SARS-CoV-2 infection: a population-based longitudinal study (COVIDENCE UK) 92%
Similar papers in this journal
- Comparative transmission of SARS-CoV-2 Omicron (B.1.1.529) and Delta (B.1.617.2) variants and the impact of vaccination: national cohort study, England 91%
- Protective effect of a first SARS-CoV-2 infection from reinfection: a matched retrospective cohort study using PCR testing data in England 90%
- Preceding anti-spike IgG levels predicted risk and severity of COVID-19 during the Omicron-dominant wave in Santa Fe city, Argentina 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.