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Atypical brain maturation in psychosis is associated with long-term cognitive decline and symptom progression

2025-04-04 psychiatry and clinical psychology Title + abstract only
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BackgroundClinical progression during psychosis has been closely associated with grey matter abnormalities resulting from atypical brain development. However, the complex interplay between psychopathology and heterogeneous maturational trajectories challenges the identification of neuroanatomical features that anticipate symptomatic decline. AimsTo investigate cortical volume longitudinal deviations in FEP using normative modelling, exploring their relationship with long-term cognitive and symp...

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