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Early Cancer Detection in Asymptomatic Subjects through Measurement of Crosslinked cf-Nucleosomes in Plasma
2025-03-20
oncology
Title + abstract only
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ABSTRACTO_ST_ABSPurposeC_ST_ABSPlasma cell-free nucleosome (cf-nucleosome) measurements are used in veterinary, but not human medicine, to identify asymptomatic subjects at high risk of cancer. Uniquely among plasma sandwich immunoassay tests, cf-nucleosomes are nucleoproteins with a complex electrochemistry. Formaldehyde crosslinking is common in the investigation of cellular nucleoproteins by chromatin immunoprecipitation. cf-nucleosome sandwich immunoassay similarly involves isolation from pl...
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