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SNP-Associated Differential Methylation in ARHGEF38: Insights into Genetic-Epigenetic Interactions

2025-03-04 psychiatry and clinical psychology Title + abstract only
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ObjectiveAssociations have been seen between suicidal behavior and differential DNA methylation of certain genes, with one study showing significant hypomethylation of ARHGEF38 in postmortem brain samples from individuals with bipolar disorder who died by suicide. Our objective was to explore ARHGEF38 methylation in individuals with bipolar disorder and a history of suicide attempt. MethodWith pyrosequencing, we looked at the previously identified region of interest in ARHGEF38. We investigated...

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