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Integrating Genome-wide and Epigenome-wide Associations for Antipsychotic Induced Extrapyramidal Side Effects
2025-02-28
psychiatry and clinical psychology
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Background and HypothesisAntipsychotic medications are the first-line treatment for schizophrenia. However, around 40% of people with schizophrenia who are treated with antipsychotics could develop extrapyramidal side-effects (EPSE) including: 1) Dyskinesias, 2) Parkinsonism, 3) Akathisia, and 4) Dystonia. Study DesignWe conducted Genome-wide association (GWAS) and Epigenome-wide association (EWAS) meta-analysis of EPSE utilising data from previous schizophrenia case control studies. We integra...
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