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PCSK9 genetic variants, carotid atherosclerosis and vascular remodelling
2025-02-27
cardiovascular medicine
Title + abstract only
View on medRxiv
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Background and aimsCirculating PCSK9 is a crucial regulator of cholesterol metabolism. Loss-of-function variants in PCSK9 are associated with lower levels of circulating low-density lipoprotein cholesterol (LDL-C) and reduced cardiovascular disease (CVD) risk, while gain-of-function variants correlate with elevated LDL-C concentrations and increased CVD risk. This study investigated whether genetically determined LDL-C levels, proxied by four PCSK9 genetic variants, influence common carotid arte...
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