Back

PennPRS: a centralized cloud computing platform for efficient polygenic risk score training in precision medicine

2025-02-10 genetic and genomic medicine Title + abstract only
View on medRxiv
Show abstract

Polygenic risk scores (PRS) are becoming increasingly vital for risk prediction and stratification in precision medicine. However, PRS model training presents significant challenges for broader adoption of PRS, including limited access to computational resources, difficulties in implementing advanced PRS methods, and availability and privacy concerns over individual-level genetic data. Cloud computing provides a promising solution with centralized computing and data resources. Here we introduce ...

Predicted journal destinations

1
Bioinformatics
24 training papers
#1 13.9%
2
The American Journal of Human Genetics
77 training papers
Top 0.7% 13.9%
3
Nature Communications
483 training papers
Top 6% 13.9%
4
Nature Genetics
72 training papers
Top 0.9% 8.8%
5
Genome Medicine
56 training papers
Top 2% 5.6%
6
Scientific Reports
701 training papers
Top 50% 5.6%
7
Genetics in Medicine
57 training papers
Top 3% 4.8%
8
Cell Genomics
34 training papers
Top 0.9% 3.7%
9
PLOS Genetics
39 training papers
Top 1% 3.7%
10
Human Genetics and Genomics Advances
39 training papers
Top 2% 2.9%
11
European Journal of Human Genetics
25 training papers
Top 3% 1.5%
12
Human Molecular Genetics
28 training papers
Top 4% 1.5%
13
eLife
262 training papers
Top 31% 1.5%
14
Frontiers in Genetics
32 training papers
Top 5% 1.3%
15
Nature
58 training papers
Top 6% 1.1%
16
Proceedings of the National Academy of Sciences
100 training papers
Top 16% 0.9%
17
PLOS ONE
1737 training papers
Top 98% 0.9%
18
npj Genomic Medicine
18 training papers
Top 4% 0.9%
19
npj Digital Medicine
85 training papers
Top 18% 0.9%
20
Circulation: Genomic and Precision Medicine
30 training papers
Top 8% 0.7%
21
Communications Biology
36 training papers
Top 7% 0.7%
22
Genes
21 training papers
Top 6% 0.7%
23
Journal of Medical Genetics
22 training papers
Top 5% 0.7%
24
Nature Medicine
88 training papers
Top 21% 0.7%
25
iScience
74 training papers
Top 14% 0.7%