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Investigating the contribution of circulating inflammatory cytokines on the link between obesity and COVID-19
2025-02-10
genetic and genomic medicine
Title + abstract only
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BackgroundCoronavirus disease 2019 (COVID-19), is more severe in individuals with obesity. Furthermore, a cytokine storm was observed in many critically ill patients with COVID-19. Since adipose tissue secretes cytokines, we investigated whether cytokines mediate the effect of obesity on COVID-19 severity. MethodsUsing two-sample Mendelian randomization analyses we assessed the causal effect of body mass index (BMI) on COVID-19 severity. We then evaluated the BMI effect on 41 inflammatory cytok...
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