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Extensive Genetic Interactions (Epistasis) Linked To Alcohol Use Disorder In A High-Risk Population
2024-12-30
addiction medicine
Title + abstract only
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Alcohol use disorder (AUD) is known to have a significant genetic component, yet there remains a substantial gap between its heritability and findings from genome-wide association studies. One potential factor contributing to this gap may be genetic interactions, or epistasis, a largely unexplored aspect in the context of AUD. The aim of this study was to investigate the role of epistasis in AUD susceptibility and severity among American Indians, a population that exhibits the highest rates of A...
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