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Exploring High LET Oxygen-Ion FLASH Radiation for Targeting Pancreatic Cancer in Vitro and In Vivo

Karle, C.; Filosa, D. I.; Akbarpour, M.; Schuhmacher, N.; Brons, S.; Cee, R.; Schoemers, C.; Scheloske, S.; Petersson, K.; Haberer, T.; Abdollahi, A.; Debus, J.; Tessonnier, T.; Moustafa, M.; Mairani, A.; Dokic, I.

2024-12-23 cancer biology
10.1101/2024.12.23.630077 bioRxiv
Show abstract

This study showcases the feasibility of oxygen ion ultra-high dose rate irradiation for in vitro and in vivo experiments at the Heidelberg Ion-Beam Therapy Center. The results indicate comparable effectiveness to standard dose rate in pancreatic cancer cell killing and tumor control, highlighting its potential to address challenges in treating radio-resistant tumors.

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