Perinatal and maternal factors associated with Autism Spectrum Disorder.
Edlund, S.; Haglund, N.; Bornehag, C.-G.; Gennings, C.; Kolevzon, A.; Kiviranta, H.; Lindh, C.; Rantakokko, P.; Reichenberg, A.; Swan, S.; Källen, K.
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This study comprehensively examines maternal and perinatal conditions associated with autism spectrum disorder (ASD) in a total population sample with individually confirmed diagnoses from South Sweden. Following thorough review of medical records, 996 cases were ascertained and classified based on level of intellectual disability, ASD severity and family-history of ASD. 10 controls per case were randomly selected from the population (N=9,960). Multiple maternal and perinatal conditions were associated with increased risk for ASD, but associations varied by ASD comorbid conditions. Only high maternal BMI was associated with ASD risk across all ASD sub-groups. Results suggest differences in ASD etiology by comorbid subgroups and highlight potential modifiable risk factors.
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