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CALIPERS: Cell cycle-aware live imaging for phenotyping experiments and regeneration studies

Di Sante, M.; Pezzotti, M.; Zimmermann, J.; Enrico, A.; Deschamps, J.; Balmas, E.; Becca, S.; Reali, A.; Bertero, A.; Jug, F.; Pasqualini, F.

2024-12-22 bioengineering
10.1101/2024.12.19.629259 bioRxiv
Show abstract

Cell cycle progression, migration, and proliferation shape development and regeneration, but simultaneous live-cell imaging remains challenging as conventional fluorescent cell cycle indicators (FUCCI) monopolize the green and red channels used by most structural and functional biosensors. To overcome this, we integrated a spectrally re-engineered FUCCI variant, open-source analysis software, and four-color human stem cell reporter lines into CALIPERS: a method for Cell-cycle-Aware Live-cell Imaging in Phenotyping and Regeneration Studies.

Published in Nature Communications (predicted rank #2) · training set

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