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Limited durability of protection conferred by XBB.1.5 vaccines against Omicron-associated severe outcomes among community-dwelling adults aged >=50 years, Ontario, Canada, September 2023 to June 2024

Lee, N.; Nguygen, L.; Nasreen, S.; Austin, P. C.; Brown, K. A.; Buchan, S. A.; Grewal, R.; Schwartz, K. L.; Tadrous, M.; Wilson, K.; Wilson, S. E.; Kwong, J. C.

2024-12-16 infectious diseases
10.1101/2024.12.14.24318807 medRxiv
Show abstract

We estimated XBB.1.5 vaccine effectiveness against hospitalization/death among adults aged [≥]50 years. Compared with non-XBB.1.5 vaccinees, the initial protection of 64% (95%CI, 57%-69%) was reduced when JN/KP-sublineages became predominant, and quickly declined. No significant protection was observed >6 months post-vaccination. Short durability of protection poses unique challenges for COVID-19 vaccination.

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