Structural, Behavioral, and Symptomatic Predictors of Risk Allele Frequency at rs10866912
Forthman, K. L.; Periyasamy, S.; Kuplicki, R.; Paulus, M. P.; Mowry, B. J.
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This study examines the distribution of risk (A) alleles at rs10866912 among 480 individuals stratified by group assignment, gender, age, race/ethnicity, body mass index (BMI), and education level. Preliminary analysis indicated higher prevalence of the risk allele in the population diagnosed with a psychiatric disorder, in concordance with past research. Linear models were applied to elucidate the relationship between the risk allele and various measures covering drug use, diet, psychiatric symptoms, neuropsychiatric ability, and structural brain measures. The findings highlight significant variations in allele frequencies across these measures, in particular egg consumption and analgesic use, which may provide insights into the mechanisms by which this genetic marker influences development of psychiatric disorders.
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