Development of a Novel Hybprinter-SAM for Functionally Graded Tissue Engineering Constructs with Patterned and Localized Biochemical Signals
Li, J.; Kim, C.; Alizadeh, H. V.; Garg, S.; Bruyas, A.; Zhao, P.; Passos, I. S. D.; Flores Perez, A. S.; Yang, Y. P.
Show abstract
Engineering native-mimetic tissue constructs is challenging due to their intricate biological and structural gradients. To address this, Hybprinter-SAM was developed by integrating three bioprinting technologies: syringe extrusion (SE), acoustic droplet ejection (ADE) and molten material extrusion (MME). This system enables not only the creation of mechanical gradients by combining soft and rigid materials but also precise patterning and controlled localization of biochemical signals within printed scaffolds. This capability is beneficial in replicating the complexity of native tissues to enhance functionality. Both the printing process and biomaterials were optimized to balance printability, mechanical integrity, and biocompatibility. As a proof of concept, Hybprinter-SAM was used in a bone-tendon regeneration study to engineer a multi-material construct with patterned fibroblast growth factor 2 (FGF-2), resulting in markers indicative of fibrocartilage development. These findings highlight the potential of Hybprinter-SAM as a versatile platform for diverse tissue engineering applications that require complex, functionally graded tissue constructs.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Embedded 3D printing in self-healing annealable composites for precise patterning of functionally mature human neural constructs 98%
- Suspended Tissue Open Microfluidic Patterning (STOMP) 96%
- Combinatorial Microgels for 3D ECM Screening and Heterogeneous Microenvironmental Culture of Primary Human Hepatic Stellate Cells 96%
Similar papers in this journal
- Particle-based hydrogel inks and support matrices for biofabricating structural complexity, soluble gradients, and cell-lined channels in fully granular bioprinted systems 97%
- Proteolytic Remodeling of 3D Bioprinted Tumor Microenvironments 97%
- Filamented Light (FLight) Biofabrication of Mini-Tendon Models Show Tunable Matrix Confinement and Nuclear Morphology 97%
Similar papers in this journal
- A Synthetic Dynamic PVA Photoresin for Fast Volumetric Bioprinting of Functional Ultrasoft Hydrogel Constructs 98%
- Gelation of Uniform Interfacial Diffusant in Embedded 3D Printing 98%
- Percolation of Microparticle Matrix Promotes Cell Migration and Integration while Supporting Native Tissue Architecture 97%
Similar papers in this journal
- Volumetric Printing across Melt Electrowritten Scaffolds Fabricates Multi-Material Living Constructs with Tunable Architecture and Mechanics 97%
- Multi-scale Engineered Vasculature and Hierarchical Porosity via Volumetric Bioprinting-guided Photopolymerization-induced Phase Separation 97%
- Xolography for Biomedical Applications: Dual-color Light-sheet Printing of Hydrogels with Local Control over Shape and Stiffness 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.