Dysregulation of synaptic-related genes within neuroimmune networks of peripheral blood mononuclear cells in major depressive disorder
Adri, A.; Nobile, A. L.; de Alburquerque, D. G.; Barcelos, P. M.; do Vale, F.; Bahia, I. A.; Freire, P.; Nava, R. G.; Correa, Y. L. G. C.; Cabral-Miranda, G.; Dalmolin, R.; Schimke, L.; Fonseca, D.; Filgueiras, I. S.; Nakaya, H.; Rezende, R. M.; Dias, H. D.; Cabral-Marques, O.
Show abstract
Major depressive disorder (MDD) involves complex neuroimmune interactions linked to gene modulation. Our study investigates synaptic-related gene dysregulation in peripheral blood mononuclear cells (PBMCs) from MDD patients, showing how these immune cells mirror neural processes. Using RNA-seq data, we identified 1,383 differentially expressed genes (DEGs) related to neuroimmune crosstalk, with 49 DEGs effectively distinguishing MDD patients from controls based on synaptic functions. Synaptic genes, enriched for roles like vesicle transport, suggest mechanistic links between immune cells and neural signaling. Eleven synaptic-related DEGs were shared between PBMCs and brain regions involved in mood regulation, highlighting a common molecular signature. Among them, ADORA3 and RPS28 emerged as potential biomarkers. These findings highlight the potential of PBMCs in the diagnosis and treatment of MDD, reinforcing the development of future neuroimmune-targeted therapies for depression.
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