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A simple method for computationally unstructuring proteins: some findings

Powell, A.

2026-03-03 biophysics
10.1101/2024.11.10.622713 bioRxiv
Show abstract

A methodology for computationally unstructuring proteins is described and the results of its application to a variety of proteins analyzed and discussed. Some proteins prove more susceptible than others, and fold topology plays a part in this. Alpha helical structure is found to be generally somewhat robust, and, perhaps unsurprisingly, unstructuring often begins at exposed chain termini. Phosphofructokinase-1 and phosphofructokinase-2, which have similar sizes but different fold topologies, are found to differ markedly in their unstructuring behaviour.

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