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Leveraging genomic large language models to enhance causal genotype-brain-clinical pathways in Alzheimer's disease

2024-10-04 genetic and genomic medicine Title + abstract only
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Genome-wide association studies (GWAS) have identified numerous Alzheimers disease (AD)- associated variants. However, how these variants contribute to the etiology of AD remains largely elusive. Recent advances in genomic large language models (LLMs) offer new opportunities to interpret the genetic variation observed in personal genome. In this study, we propose epiBrainLLM, a novel computational framework that leverages genomic LLM to enhance our understanding of the causal pathways from genot...

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