Back

In vivo Antibody Painting for Next Generation Weight Loss Drugs

Kitahara, K.; Rondon, A.; Miller, E.; Mak, H. H.; Loas, A.; Pentelute, B. L.

2024-08-23 bioengineering
10.1101/2024.08.22.609257 bioRxiv
Show abstract

Peptide-based therapeutics are currently in great demand but often suffer from rapid clearance and accumulation in off-target tissues which continue to present barriers in their clinical translation. Here, we developed an electrophilic peptide for the attachment of therapeutics to native immunoglobulin (IgG) in vivo, enabling the bioorthogonal covalent linkage, or painting, of peptide drugs of choice to circulating IgGs directly in live animals. Native IgG painting with glucagon-like peptide-1 (GLP-1) results in sustained body weight loss and prolonged blood glucose management after one dose. Such technology might revolutionize the next generation of long-acting peptide-based medicines.

Matching journals

The top 6 journals account for 50% of the predicted probability mass.

1
Nature Communications
○ 5641 papers in training set
Top 14%
12.8%
2
ACS Central Science
● 71 papers in training set
Top 0.1%
11.8%
3
Journal of the American Chemical Society
● 217 papers in training set
Top 0.3%
9.7%
4
Angewandte Chemie International Edition
○ 93 papers in training set
Top 0.2%
6.7%
5
Science Advances
● 1243 papers in training set
Top 3%
6.2%
6
Advanced Science
○ 286 papers in training set
Top 1%
5.5%
50% of probability mass above
7
Cell Chemical Biology
○ 94 papers in training set
Top 0.2%
5.4%
8
Nature Biomedical Engineering
○ 47 papers in training set
Top 0.2%
4.8%
9
Nature Chemistry
○ 42 papers in training set
Top 0.3%
3.2%
10
Nature Chemical Biology
○ 119 papers in training set
Top 0.8%
3.2%
11
Nature Nanotechnology
○ 32 papers in training set
Top 0.2%
2.6%
12
Proceedings of the National Academy of Sciences
● 2444 papers in training set
Top 22%
2.4%
13
Advanced Materials
○ 56 papers in training set
Top 0.6%
1.7%
14
ACS Nano
● 113 papers in training set
Top 1%
1.7%
15
Advanced Healthcare Materials
○ 85 papers in training set
Top 1%
1.3%
16
ACS Chemical Biology
● 167 papers in training set
Top 2%
1.1%
17
iScience
○ 1154 papers in training set
Top 30%
1.0%
18
Chemical Science
● 73 papers in training set
Top 2%
0.9%
19
Communications Biology
○ 993 papers in training set
Top 31%
0.8%
20
Nature Biotechnology
○ 172 papers in training set
Top 4%
0.8%
21
Science
● 477 papers in training set
Top 9%
0.8%
22
Advanced Functional Materials
○ 46 papers in training set
Top 1%
0.8%
23
Cell
○ 431 papers in training set
Top 10%
0.8%
24
Molecular Therapy
○ 81 papers in training set
Top 2%
0.6%
25
Cell Reports Medicine
○ 153 papers in training set
Top 6%
0.6%
26
Cell Reports
○ 1498 papers in training set
Top 29%
0.6%
27
Bioconjugate Chemistry
● 20 papers in training set
Top 0.4%
0.6%