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Staphylococcus aureus Tetracycline Resistance and Co-Resistance in a Doxy-PEP Eligible Population

Mittelstaedt, R.; Kanjilal, S.; Helekal, D.; Robbins, G. K.; Grad, Y. H.

2024-08-22 infectious diseases
10.1101/2024.08.22.24312434 medRxiv
Show abstract

In Staphylococcus aureus infections in men eligible for doxycycline post-exposure prophylaxis (doxy-PEP), tetracycline non-susceptibility is more prevalent than in the overall population and is associated with resistance to trimethoprim-sulfamethoxazole and clindamycin. Doxy-PEP may select for S. aureus multi-drug resistance, underscoring the importance of surveillance.

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