Magnetic Activation of Spherical Nucleic Acids for the Remote Control of Synthetic Cells
Parkes, E.; Al Samad, A.; Mazzotti, G.; Newell, C.; Ng, B.; Radford, A.; Booth, M. J.
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The advancement of synthetic cells as drug delivery devices hinges on the development of targeting strategies, in particular the controlled synthesis of biomolecules in-situ using a deeply penetrative stimulus. To address this, we have designed spherical nucleic acids comprising DNA promoter sequences decorating magnetic nanoparticle cores. By harnessing the heat dissipated from magnetic hyperthermia (a clinically-approved anticancer therapy) we tightly controlled cell-free protein synthesis. We then deployed a tissue phantom that is impenetrable by current activation methods to demonstrate the potential of this technology for the remote control of synthetic cells using deeply tissue-penetrating magnetic fields. This paves the way for targeting and controlling the in-situ synthesis of biomolecules deep within the body. O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=181 SRC="FIGDIR/small/608917v1_ufig1.gif" ALT="Figure 1"> View larger version (46K): org.highwire.dtl.DTLVardef@3cf352org.highwire.dtl.DTLVardef@18a8da3org.highwire.dtl.DTLVardef@159018aorg.highwire.dtl.DTLVardef@744529_HPS_FORMAT_FIGEXP M_FIG C_FIG
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