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Widespread environment-specific causal effects detected in the UK Biobank

2024-08-21 epidemiology Title + abstract only
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BackgroundMendelian Randomization (MR) is a widely used tool to infer causal relationships. Yet, little research has been conducted on the elucidation of environment specific causal effects, despite mounting evidence for the relevance of causal effect modifying environmental variables. MethodsTo investigate potential modifications of causal effects, we extended two-stage-least-squares MR to investigate interaction effects (2SLS-I). We first tested 2SLS-I in a wide range of realistic simulation ...

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