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BMI-related Genetic Factors and COPD Imaging Phenotypes

2024-08-20 respiratory medicine Title + abstract only
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BackgroundWhile low body mass index (BMI) is associated with emphysema and obesity is associated with airway disease in chronic obstructive pulmonary disease (COPD), the underlying mechanisms are unclear. MethodsWe aggregated genetic variants from population-based genome-wide association studies to generate a polygenic score of BMI (PGSBMI). We calculated this score for participants from COPD-enriched and community-based cohorts and examined associations with automated quantification and visual...

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