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The transcriptome of CD14+CD163-HLA-DRlow monocytes predicts mortality in Idiopathic Pulmonary Fibrosis

2024-08-08 respiratory medicine Title + abstract only
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RationaleThe association between immune-cell-specific transcriptomic profiles and Idiopathic Pulmonary Fibrosis (IPF) mortality is unknown. ObjectivesTo determine immune-cell-specific transcriptomic profiles associated with IPF mortality. MethodsWe profiled peripheral blood mononuclear cells (PBMC) in 18 participants [University of South Florida: IPF, COVID-19, post-COVID-19 Interstitial Lung Disease (Post-COVID-19 ILD), controls] by single-cell RNA sequencing (scRNA-seq) and identified 16 imm...

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