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Sex-Specific causal dynamic between Insulin resistance and MDD, a bidirectional Mendelian randomization study.
2024-07-16
psychiatry and clinical psychology
Title + abstract only
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Aims/hypothesisObservational studies have shown a bidirectional association between major depressive disorder (MDD), Insulin resistance (IR), and related diseases, which varies between sexes and ancestries. We conducted a sex-specific two-sample bidirectional Mendelian randomization (MR) study to assess the causal associations of MDD with Insulin resistance measured through the TG: HDL-C ratio and vice versa using Caucasian and East Asian data. MethodsWe extracted summary-level data for MDD and...
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