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Probing the Biological Underpinnings of Advanced Brain Ageing in Schizophrenia

2024-07-05 psychiatry and clinical psychology Title + abstract only
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BackgroundRecent evidence suggests that patients with schizophrenia may show advanced brain ageing, particularly evident after the first year of onset. However, it is unclear if accelerated ageing relents, persists or continues to increase over time. The underlying causal factors are also poorly understood. Disruptions in glutamate function, oxidative stress, and inflammation may all contribute to progressive brain changes in people with schizophrenia. We examine whether brain ageing differs bet...

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