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TEtrimmer: a novel tool to automate the manual curation of transposable elements

QIAN, J.; Xue, H.; Ou, S.; Storer, J. M.; Fuertauer, L.; Wildermuth, M. C.; Kusch, S.; Panstruga, R.

2024-07-02 bioinformatics
10.1101/2024.06.27.600963 bioRxiv
Show abstract

Transposable elements (TEs) are repetitive DNA sequences capable of moving within genomes. Accurate annotation and classification of TEs is crucial but challenging due to their sequence diversity and often fragmented occurrence. We present TEtrimmer, a novel tool to automate manual TE curation. TEtrimmer integrates multiple sequence alignment (MSA) clustering, MSA sequence extension, MSA cleaning, TE boundary definition, and TE classification, and provides report plots and a graphical user interface (GUI) application to inspect and improve results. Benchmarked on the genomes of six organisms from various kingdoms of life, TEtrimmer consistently improved the identification of intact TEs compared to established tools.

Published in Nature Communications (predicted rank #12) · training set

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Top 4%
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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.